Abstract
Anxiety disorders are one of the most common psychiatric disorders presenting to the family physician. Anxiety disorders are both biologic and psychologic in origin. Anxiety is a signal alerting the individual of ‘danger.’ This danger can be unknown, internal, conflictual and vague. The anxiety signal allows the individual to respond to, and resolve the ‘danger.’ This is to be differentiated from fear which is the emotional response to a real or perceived imminent threat. These two states overlap but differ in that fear more often triggers the physiologic response of fight or flight. Anxiety disorders result when one or both of these systems are in a chronic ‘hyper reactive’ state for either biologic or psychologic reasons. This article reviews the criteria for anxiety disorders and the range of therapeutic interventions, pharmacologic and non-pharmacologic.
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INTRODUCTION
Anxiety disorders are one of the most common psychiatric disorders presenting to the family physician. Anxiety disorders are both biologic and psychologic in origin. Anxiety is a signal alerting the individual of ‘danger.’ This danger can be unknown, internal, conflictual and vague. The anxiety signal allows the individual to respond to, and resolve the ‘danger.’ This is to be differentiated from fear which is the emotional response to a real or perceived imminent threat.1 These two states overlap but differ in that fear more often triggers the physiologic response of fight or flight.
Anxiety disorders result when one or both of these systems are in a chronic ‘hyper reactive’ state for either biologic or psychologic reasons. A brief example is making a presentation to your department at work. This situation is likely to trigger a small degree of anxiety in all individuals which allows the individual to take steps to make sure the presentation goes well such as checking the materials to be presented for accuracy and clarity. Once the materials are re- viewed the individual feels confident and successfully completes the presentation. If the anxiety/fear systems are hyper reactive the individual may experience a panic attack with a range of physiologic responses such are rapid heart rate, hyperventilation, and light headedness to name a few. This physiologic response is clearly inappropriate as this is not a life and death situation in which we need the fight and flight response for survival. In this situation the presentation may not occur possibly resulting in negative outcome for the individual.
Anxiety disorders often start in childhood and must be differentiated from normal childhood worries. Pediatricians and family physicians are familiar with the startle of infants and the fear of monsters in the toddler years. The preschool age child has fears about safety such as being kidnapped or worries about storms, thunder and lightning. These worries may persist into the school age years with the addition of worries related to school performance and social relationships and/or rejection. Fear of bodily harm and illness may arise during this time. Through the teenage years the main worry is about performance, both social and academic.
Life time prevalence of any anxiety disorder in children and adolescents is between 15% and 32%, and the period prevalence (one year or six months) for any anxiety disorder ranges from 3.1% to 18%.2,3 Children with anxiety disorders are at greater risk of developing substance abuse and conduct problems and have increased use of long-term psychiatric and medical services and greater overall functional impairment.3,4
One in four adults have been found to have an anxiety disorder. A replication of the National comorbidity study by Kessler, et al. found an 18.1% 12-month prevalence rate for any Diagnostic and Statistical Manual of Mental Disorders IV (DSM IV) anxiety disorder.5
EVALUATION & DIAGNOSIS (CRITERIA)
Anxiety disorders overlap but can be differentiated based on the particular presentation of symptoms. Identifying and treating anxiety disorders early can prevent long term morbidity. Mandates for improved mental health screening in the family practice medical home are based on the affordable care act.6 This includes screening for children, youth, and adults.
Use of validated rating scales in conjunction with the patient interview and examination can assist the busy clinician in evaluating for and following treatment of anxiety. Below are key features of the main anxiety disorders followed by abbreviated Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) criteria. Validated rating scales that may be used at no cost are referenced under each diagnosis. See the DSM-5 for complete diagnostic criteria.1
TREATMENT
Treatment of the patient with an anxiety disorder is based on the evaluation and resultant biopsychosocial formulation for that patient (part of the five model approach to osteopathic patient centered care). This may range from parent guidance for the young child with separation anxiety to aggressive pharmacologic interventions with referral to a mental health specialist or child and adolescent psychiatrist for evaluation and therapy. Osteopathic manipulative medicine should be considered as part of the overall treatment plan for the patient.
In general, Cognitive Behavioral Therapy (CBT) is the treatment of choice for all anxiety disorders, alone or in combination with medications and other interventions.
COGNITIVE BEHAVIORAL THERAPY:
Although cognitive behavioral therapy is typically provided by a therapist for anxiety, depression, and other mental health disorders, the family practice physician can learn the underlying principals and skills necessary to assist their patients achieve improved mental health.
Cognitive behavioral therapy (CBT) was develop by Aaron Beck, MD, a psychoanalyst, in the early 1960s. CBT grew out of Dr. Beck’s research on the psychoanalytic theory of depression. His research, which Dr. Beck expected would validate the psychoanalytic therapy of depression, ‘anger turned toward the self’, did just the opposite. Rather, distorted thoughts and beliefs were the primary feature of depression.7 Cognitive behavioral therapy assumes that a patient's misconceptions and attitudes about the world and themselves precede and produce symptoms such as anxiety and depression. Therapy identifies habitual ways in which patients distort information (e.g., automatic thoughts) and teaches patients to identify, evaluate, and respond to their dysfunctional thoughts and beliefs, using a variety of techniques to change thinking, mood, and behavior. Cognitive therapy is a structured, goal-oriented, problem-focused, and time-limited intervention. This active approach involving principles of learning, help the patient develop new and adaptive ways of behaving. Treatment also attempts to alter behavior by systematically changing the environment that pro- duces the behavior; such behavioral changes are believed to lead to changes in thoughts and emotions. Beck’s treatment model is based on what he terms the cognitive formulation; the beliefs and behavioral strategies that characterize a specific disorder (Alford and Beck, 1997).
The cognitive formulation is an understanding of the patients’ problems and an understanding of the patient’s thinking related to the problem. This includes the current thinking that contributes to the problem (“I can’t lose weight, I’m a failure, I’ll always be fat.”).
The problematic behaviors (drinking a soda rather than water or driving one block to pick up a child rather than walking). And the developmental events or patterns of thinking that predisposed or hold the behaviors causing the problem (developed earlier than many children and was teased, becoming overly self-conscious and critical of self).
The process of treatment is based on the cognitive formulation with the key goal of having the patient identify and change dysfunctional thinking (cognitions).
PSYCHOEDUCATION
For the purpose of this article, psychoeducation refers to the didactic informing of patients and their relatives about the illness, its treatment, and empowerment to handle the illness.8 Psycho-education has been shown to be as effective as CBT for youth with anxiety disorders.9 Goals for psychoeducation include;8
Ensuring patients and their family/relatives have a basic understanding of the illness and treatment
Empowering the patient and family/relatives to handle the illness
Helping the patient take on the role of the “expert”
Strengthen the role of family/relatives
Information to improve treatment compliance
Relapse prevention
Crisis management and prevention
Support healthy choices
NUTRITION
The osteopathic physician is skilled at communicating the importance of healthy nutrition for physical, mental and emotional health. There is considerable debate on the effect or usefulness of supplements in the treatment of mental health disorders. The support for nutritional supplements is strongest for depressive disorders with more limited support for anxiety disorders. Because depression and anxiety are frequently comorbid it may be helpful to consider the complementary and alternative medicine (CAM) treatments for depression. The most support can be found for the B vitamins, Omega-3 Fatty Acids, and inositol.10 A review study by Shaheen Lakah, et al.11 found evidence for the use of herbal supplements containing extracts of passionflower or kava and combinations of L-lysine and L-arginine as treatments for anxiety symptoms and disorders. It should be noted Kava has been removed from the market secondary to concerns for hepatic toxicity.
EXERCISE
As with nutrition, the osteopathic physician is skilled at communicating the importance of exercise for physical, mental and emotional health. Both exercise and yoga have support for their use in anxiety disorders. 12,13
OSTEOPATHIC INTERVENTIONS
In the five-model approach to osteopathic patient centered care, anxiety disorders fall under the biopsychosocial model. Though there is much research on the effectiveness of cognitive behavioral therapy in anxiety, research in OMT intervention and anxiety is scant. Recent research on the rat model has demonstrated that cannabinoid receptor agonism suppresses anxiety like behavior in rats with essential tremor.14 We have a body of research theorizing that OMT increases endocannabinoids in the brain through stimulation of the periaqueductal grey matter as well as down-regulates sympathetic stimulation through the Vagus nerve, Cranial Nerve X.15
Stephen W Porges, Ph D, discusses a polyvagal theory in vertebrates, in which the action of the autonomic nervous system can vary based on phylogenetic stages of development. These autonomic subsystems are social communication, mobilization and immobilization, and each are used in to provide an adaptive response in safe, dangerous and life-threatening events.16
Regardless of the cause, often the ANS becomes activated and never fully return to a pre-traumatic state of functioning, thus anxiety results. We can see this physiologically in the heart rate variability, where low variability is associated with a high sympathetic tone. Yergagani et al found low heart rate variability correlated with emotional disorders in children.17 This enhanced stress reactivity in pediatric patients’ increases all- cause mortality and can be a possible predictor for future cardiovascular events.18
Given the correlation of heart rate variability, the best results using OMT would be likely achieve using techniques that affect the heart rate variability. Cervical HVLA has been shown to improve heart rate variability in one study of volunteer patients with neck pain.19 Osteopathic cranial manipulative medicine has been felt to affect the heart rate variability through upregulation of the parasympathetic nervous system. Proximity to this region is likely a factor for the effectiveness of these techniques. Listed below is a possible treatment regime for the patient with anxiety. Obviously, the physician must use clinical judgment to know if the patient is appropriate to receive an osteopathic treatment, and permission should be obtained prior.
Cervical Soft Tissue/long axis kneeding – this technique is performed by having the physician at the head of the table. With fingertips lateral to the spinous processes, the physician uses a superior and lateral pressure on the entire length of the cervical spine.
Cervical High Velocity/Low Amplitude – As described above, cervical HVLA, either sidebending or rotational focus, is thought to improve heart rate variability. Somatic dysfunction barrier is engaged in the cervical spine and short quick thrust applied to localized segment at the end of patient.
Sacral decompression – Due to the proximity of the para-sympathetic nervous system to the sacral region, a simple sidelying sacral decompression in appropriate patients may helpful to decreasing the level of a patients’ perceived anxiety. The patient place the thenar and hypothenar eminence over the base of the sacrum at L5 and uses a constant pressure inferior for a period of 1-3 minutes.
FIGURE 1:
Suboccipital/oa decompression
FIGURE 2:
Doming of the thoracic diaphragm
Suboccipital/OA decompression- Thought to be beneficial due to the proximity of the Vagus nerve. The patient lies supine on the table while physician placed index and middle fingers in the suboccipital musculature. Anterior pressure is held for a period of 1-3 minutes until relaxation is felt.20
Doming of the respiratory diaphragm – Patient is in the supine position, physician inserts thumbs under the costal margin but lateral to the xyphoid process and has the patient breath in and out while exerting a superior pressure on the thumbs.
Compression of the Fourth Ventricle – An OCMM technique that address the periaqueductal grey area around the fourth ventricle. The physician sits at the head of the supine patient. Physician’s hands are placed palmer side up and medial to the occipitomastoid suture. Using thenar eminances on the occiput the physician encourages cranial extension while discouraging cranial flexion until a ‘still point’ is achieved.21
This protocol is just one possible scenario for anxiety which can be performed in approximately 10 minutes at the bedside of the patient, or in the office setting. Additionally, coherence training can be helpful as an adjuctive or take home exercise. Many offices have handheld biofeedback tools, such as the “EmWave” that help the patient with improving heart rate variability. Even without the devices, focused mindful breathing can be very helpful in decreasing anxiety levels and can be used in any setting.
PHARMACOLOGIC MANAGEMENT
Note: Hydroxyzine is only medication that has FDA approval for treatment of children (≥ 6 years) with anxiety. A range of medications are used off label in the treatment of anxiety disorders in children and will be included as supported by the literature.
Separation Anxiety Disorder (ICD 10 code F93.0)
In children the treatment of choice for separation anxiety disorder is CBT with parent guidance and/or Parent-Child Interaction Therapy (PCIT). If medications are considered the SSRI medications are effective and considered the first line pharmacologic treatment. There is evidence for sertraline (25-200mg daily), fluoxetine (20mg daily), and fluvoxamine (50-250 mg daily).4
Although there is little research in adults with separation anxiety disorder, CBT and the SSRI medications are considered the treatment of choice.
Social Anxiety Disorder (ICD 10 code F40.10)
All SSRI medications are effective and considered the first line pharmacologic treatment of social anxiety disorder. Dosing strategies for the SSRI medications are the same as for depressive disorders. Venlafaxine 75mg daily (may use higher doses) also demonstrated effectiveness. Buspirone (max dose 60mg/day as bid dosing) has been shown to be effective when used to augment the SSRI medications.22
Benzodiazepine (alprazolam 1-6mg daily and clonazepam 0.25- 3mg daily) are effective in the treatment of social anxiety at standard doses. Use of Benzodiazepines is considered short term for a period of weeks. The most common clinical mistake utilizing benzodiazepines for treatment is to continue treatment indefinitely.
The MAOI medications including phenelzine (15-90mg daily as tid) have been reported to be effective in cased of severe social anxiety disorder.
Treatment of social anxiety disorder of the performance type can be effective treated with the beta adrenergic receptor antagonistic medications atenolol (50-100mg about one or two hours prior to the event) and propranolol (20-40mg one or two hours prior to the event) or the benzodiazepines lorazepam and alprazolam.
Panic Disorder (ICD 10 code F41.0)
All SSRI medications are effective and considered the first line pharmacologic treatment of panic disorder. The particular agent chosen is based on the particular effects of the medication such as sedation, activation, and weight gain. Paroxetine is more sedating and calming but also has increased weight gain compared to other SSRI agents. Citalopram, escitalopram, sertraline, and fluvoxamine are next best tolerated. Fluoxetine can be activating and should be started a low dose such as 10mg daily and titrated upward slowly.22
Clomipramine and imipramine have demonstrated effectiveness in the treatment of panic disorder. Desipramine (100-200mg daily) has limited evidence. The tricyclic agents are less widely used than the SSRIs because of the increased adverse effects that are seen at the doses needed for clinical response.22
MAOI medications including phenelzine (15-90mg daily as tid) and tranylcypromine (30-60mg daily) have data to support their use in panic disorder. The dietary restrictions limit their use.22
The atypical antidepressant venlafaxine is effective in the panic disorder but is considered second line treatment to the SSRI medications. Buspirone (max dose 60mg/day as bid dosing) has been suggested as an augmentation to other medications for panic dis- order.22
If a patient fails to respond to one class of medications changing to another class of medications is suggested.
Alprazolam (3-6mg daily) is a benzodiazepine that is FDA approved for panic disorder. Based on the current trend to avoid the possible longer term complications of the benzodiazepines they have not been included as a primary treatment for panic disorder.22
Generalized Anxiety Disorder (ICD 10 code F41.1)
For adults, the benzodiazepines have long been considered the drug of choice for generalized anxiety disorder (GAD) prescribed for a short course or on an ‘as needed’ basis. Based on the current trend to avoid the possible longer term complications of the benzodiazepines alternative medications such as the SSRI medications, Venlafaxine, and Buspirone are effectively utilized for GAD. As previously noted, the most common mistake in utilizing the benzodiazepines is ongoing, indefinite treatment. The benzodiazepines with an intermediate half-life are typically utilized in GAD (alprazolam, clonazepam, lorazepam).22
Buspirone (max 60mg daily) have been suggested to be effective in 60-80% of individuals with GAD. Individuals previously treated with benzodiazepines do not demonstrate this response. Some studies suggest use of benzodiazepines with buspirone as they appear to target different aspects of the anxiety.22
Venlafaxine (37.5-225mg daily) has demonstrated effectiveness for GAD.
SSRI medications have demonstrated effectiveness for GAD al- though few have an FDA indication for this purpose (paroxetine and escitalopram). There is some concern that the SSRI medications may initially increase the level of anxiety. The SSRI medications are often prescribed in conjunction with a 2-3 week course of benzodiazepines.22
The beta adrenergic agents such as atenolol and propranolol may be used to address the physiologic response and somatic symptoms of anxiety. These agents do not treat the underlying anxiety disorder.22
Post Traumatic Stress Disorder (ICD 10 code F43.10)
Trauma focused cognitive behavioral therapy (TF-CBT) is considered the primary treatment for post-traumatic stress disorder (PTSD). Eye movement desensitization reprocessing (EMDR) is also commonly utilized. Both TF-CBT and EMDR require a clinician with specialized training.
All SSRI medications are effective and considered the first line pharmacologic treatment of PTSD. The particular agent chosen is based on the particular effects of the medication such as sedation, activation, and weight gain. Paroxetine is more sedating and calming but also has increased weight gain compared to other SSRI agents. Citalopram, escitalopram, sertraline, and fluvoxamine are next best tolerated. Fluoxetine can be activating and should be started a low dose such as 10mg daily and titrated upward slowly.22
Minipress (1-15mg at bedtime) is effective for the nightmares/sleep disorder associated with PTSD.23
The tricyclic agents imipramine (100-200mg daily) and amitriptyline (75-300mg daily) also have clinical data supporting their effectiveness
in PTSD. The minimum trial of the tricyclic agents should be eight weeks.22
Other medications that may be useful in the treatment of PTSD include phenelzine, trazodone, and the anticonvulsants (e.g., carbamazepine, valproate).²2
CONCLUSION
Anxiety is a multifactorial disease process which requires an individualized treatment plan for each patient. Treatment may include cognitive behavioral therapy, psychoeducation nutritional support, medications and osteopathic manipulative medicine. When used in conjunction with osteopathic manipulative medicine, the biopsychosocial approach of the five models of osteopathic care will assist in decreasing symptoms and support the treatment of the patient with anxiety.
Please view the PDF for diagnostic criteria for each disorder.
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